{"id":1544,"date":"2017-04-09T06:05:04","date_gmt":"2017-04-09T04:05:04","guid":{"rendered":"https:\/\/wissen.science-and-fun.de\/chemistry\/?p=1544"},"modified":"2017-04-29T08:20:16","modified_gmt":"2017-04-29T06:20:16","slug":"glutamine-gln-q","status":"publish","type":"post","link":"https:\/\/wissen.science-and-fun.de\/chemistry\/2017\/04\/09\/glutamine-gln-q\/","title":{"rendered":"Glutamine (Gln, Q)"},"content":{"rendered":"<h3>NMR-Data [1] of Glutamine:<\/h3>\n<table style=\"width: 1103px;\" border=\"1\">\n<tbody>\n<tr>\n<th style=\"width: 186px;\" rowspan=\"17\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"alignleft size-full wp-image-6088\" src=\"https:\/\/i0.wp.com\/wissen.science-and-fun.de\/wp-content\/uploads\/2014\/02\/glutamin.png?resize=196%2C132&#038;ssl=1\" alt=\"Glutamin\" width=\"196\" height=\"132\" \/><\/th>\n<th style=\"width: 45px;\" rowspan=\"2\" valign=\"top\">Atom<\/th>\n<th style=\"width: 71px;\" rowspan=\"2\" valign=\"top\">Atomtyp<\/th>\n<th style=\"width: 411px;\" colspan=\"3\">chemical shift [ppm]<sup>1<\/sup><\/th>\n<th style=\"width: 113px;\" rowspan=\"2\">Random Coil<br \/>\nchem. shift\u00a0<sup>3<\/sup><\/th>\n<th style=\"width: 227px;\" rowspan=\"2\">Random Coil<br \/>\nchem. shift\u00a0<sup>4<\/sup><\/th>\n<\/tr>\n<tr>\n<td style=\"width: 130px;\"><strong>average<\/strong><\/td>\n<td style=\"width: 176px;\"><strong>standard deviation<\/strong><\/td>\n<td style=\"width: 105px;\"><strong>entries<sup>2<\/sup><\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 45px;\">H<\/td>\n<td style=\"width: 71px;\">H<\/td>\n<td style=\"width: 130px;\">\u00a08.218<\/td>\n<td style=\"width: 176px;\">\u00a00.684<\/td>\n<td style=\"width: 105px;\">\u00a033299<\/td>\n<td style=\"width: 113px;\">\u00a08.32<\/td>\n<td style=\"width: 227px;\">\u00a08.29<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 45px;\">H\u03b1<\/td>\n<td style=\"width: 71px;\">H<\/td>\n<td style=\"width: 130px;\">\u00a04.268<\/td>\n<td style=\"width: 176px;\">\u00a00.439<\/td>\n<td style=\"width: 105px;\">\u00a025740<\/td>\n<td style=\"width: 113px;\">\u00a04.34<\/td>\n<td style=\"width: 227px;\">\u00a04.65<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 45px;\">H\u03b22<\/td>\n<td style=\"width: 71px;\">H<\/td>\n<td style=\"width: 130px;\">\u00a02.042<\/td>\n<td style=\"width: 176px;\">\u00a00.273<\/td>\n<td style=\"width: 105px;\">\u00a023494<\/td>\n<td style=\"width: 113px;\">\u00a02.12<\/td>\n<td style=\"width: 227px;\">\u00a02.09<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 45px;\">H\u03b23<\/td>\n<td style=\"width: 71px;\">H<\/td>\n<td style=\"width: 130px;\">\u00a02.012<\/td>\n<td style=\"width: 176px;\">\u00a00.317<\/td>\n<td style=\"width: 105px;\">\u00a022302<\/td>\n<td style=\"width: 113px;\">\u00a01.99<\/td>\n<td style=\"width: 227px;\">\u00a01.93<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 45px;\">H\u03b32<\/td>\n<td style=\"width: 71px;\">H<\/td>\n<td style=\"width: 130px;\">\u00a02.312<\/td>\n<td style=\"width: 176px;\">\u00a00.351<\/td>\n<td style=\"width: 105px;\">\u00a022128<\/td>\n<td style=\"width: 113px;\">\u00a02.36<\/td>\n<td style=\"width: 227px;\">\u00a02.38<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 45px;\">H\u03b33<\/td>\n<td style=\"width: 71px;\">H<\/td>\n<td style=\"width: 130px;\">\u00a02.29<\/td>\n<td style=\"width: 176px;\">\u00a00.38<\/td>\n<td style=\"width: 105px;\">20418<\/td>\n<td style=\"width: 113px;\">\u00a02.36<\/td>\n<td style=\"width: 227px;\">\u00a02.38<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 45px;\">H\u03b521<\/td>\n<td style=\"width: 71px;\">H<\/td>\n<td style=\"width: 130px;\">\u00a07.212<\/td>\n<td style=\"width: 176px;\">\u00a00.508<\/td>\n<td style=\"width: 105px;\">\u00a016963<\/td>\n<td style=\"width: 113px;\">\u00a07.52<\/td>\n<td style=\"width: 227px;\">\u00a07.53<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 45px;\">H\u03b522<\/td>\n<td style=\"width: 71px;\">H<\/td>\n<td style=\"width: 130px;\">\u00a07.04<\/td>\n<td style=\"width: 176px;\">\u00a00.96<\/td>\n<td style=\"width: 105px;\">\u00a016868<\/td>\n<td style=\"width: 113px;\">\u00a06.85<\/td>\n<td style=\"width: 227px;\">\u00a06.88<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 45px;\">C<\/td>\n<td style=\"width: 71px;\">C<\/td>\n<td style=\"width: 130px;\">\u00a0176.381<\/td>\n<td style=\"width: 176px;\">\u00a011.294<\/td>\n<td style=\"width: 105px;\">\u00a021300<\/td>\n<td style=\"width: 113px;\">\u00a0176.0<\/td>\n<td style=\"width: 227px;\">\u00a0174.4<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 45px;\">C\u03b1<\/td>\n<td style=\"width: 71px;\">C<\/td>\n<td style=\"width: 130px;\">\u00a056.593<\/td>\n<td style=\"width: 176px;\">\u00a02.184<\/td>\n<td style=\"width: 105px;\">\u00a029520<\/td>\n<td style=\"width: 113px;\">\u00a055.7<\/td>\n<td style=\"width: 227px;\">\u00a053.7<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 45px;\">C\u03b2<\/td>\n<td style=\"width: 71px;\">C<\/td>\n<td style=\"width: 130px;\">\u00a029.211<\/td>\n<td style=\"width: 176px;\">\u00a02.091<\/td>\n<td style=\"width: 105px;\">\u00a027695<\/td>\n<td style=\"width: 113px;\">\u00a029.4<\/td>\n<td style=\"width: 227px;\">\u00a028.8<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 45px;\">C\u03b3<\/td>\n<td style=\"width: 71px;\">C<\/td>\n<td style=\"width: 130px;\">\u00a033.783<\/td>\n<td style=\"width: 176px;\">\u00a01.829<\/td>\n<td style=\"width: 105px;\">\u00a019117<\/td>\n<td style=\"width: 113px;\">\u00a033.7<\/td>\n<td style=\"width: 227px;\">\u00a033.4<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 45px;\">C\u03b4<\/td>\n<td style=\"width: 71px;\">C<\/td>\n<td style=\"width: 130px;\">\u00a0179.252<\/td>\n<td style=\"width: 176px;\">\u00a07.944<\/td>\n<td style=\"width: 105px;\">\u00a02022<\/td>\n<td style=\"width: 113px;\">\u00a0180.5<\/td>\n<td style=\"width: 227px;\">\u00a0180.5<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 45px;\">N<\/td>\n<td style=\"width: 71px;\">N<\/td>\n<td style=\"width: 130px;\">\u00a0119.871<\/td>\n<td style=\"width: 176px;\">\u00a03.968<\/td>\n<td style=\"width: 105px;\">\u00a031370<\/td>\n<td style=\"width: 113px;\">\u00a0119.8<\/td>\n<td style=\"width: 227px;\">\u00a0120.6<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 45px;\">N\u03b52<\/td>\n<td style=\"width: 71px;\">N<\/td>\n<td style=\"width: 130px;\">\u00a0111.86<\/td>\n<td style=\"width: 176px;\">\u00a02.146<\/td>\n<td style=\"width: 105px;\">\u00a015151<\/td>\n<td style=\"width: 113px;\">\u00a0112.1<\/td>\n<td style=\"width: 227px;\">\u00a0112.1<\/td>\n<\/tr>\n<tr>\n<th style=\"width: 186px;\">proportion of proteines<\/th>\n<th style=\"width: 116px;\" colspan=\"2\">pK<sub>2<\/sub> COOH<\/th>\n<th style=\"width: 130px;\">pK<sub>1<\/sub>COOH<\/th>\n<th style=\"width: 281px;\" colspan=\"2\">isoelectrical<br \/>\npoint<\/th>\n<th style=\"width: 113px;\">pK<sub>1<\/sub>NH<sub>2<\/sub><\/th>\n<th style=\"width: 227px;\">pK<sub>2<\/sub>NH<sub>2<\/sub><\/th>\n<\/tr>\n<tr>\n<td style=\"width: 186px;\">\u00a07.5%<\/td>\n<td style=\"width: 116px;\" colspan=\"2\">\u00a0&#8211;<\/td>\n<td style=\"width: 130px;\">\u00a02.17<\/td>\n<td style=\"width: 281px;\" colspan=\"2\">\u00a05.65<\/td>\n<td style=\"width: 113px;\">\u00a09.13<\/td>\n<td style=\"width: 227px;\">\u00a0&#8211;<\/td>\n<\/tr>\n<tr>\n<th style=\"width: 186px;\">CAS- number<\/th>\n<th style=\"width: 116px;\" colspan=\"2\">molar mass<\/th>\n<th style=\"width: 130px;\">formula<\/th>\n<th style=\"width: 281px;\" colspan=\"2\">density<\/th>\n<th style=\"width: 113px;\">melting point<\/th>\n<th style=\"width: 227px;\">solubility<\/th>\n<\/tr>\n<tr>\n<td style=\"width: 186px;\">\n<ul>\n<li>56-85-9 (<small>L<\/small>-Enantiomer)<\/li>\n<li>5959-95-5 (<small>D<\/small>-Enantiomer)<\/li>\n<li>585-21-7 (<small>DL<\/small>-glutamine)<\/li>\n<\/ul>\n<\/td>\n<td style=\"width: 116px;\" colspan=\"2\">\u00a0146,15 g\u00b7mol<sup>\u22121<\/sup><\/td>\n<td style=\"width: 130px;\">\u00a0C<sub>5<\/sub>H<sub>10<\/sub>N<sub>2<\/sub>O<sub>3<\/sub><\/td>\n<td style=\"width: 281px;\" colspan=\"2\"><\/td>\n<td style=\"width: 113px;\">\u00a0185\u2013186\u00a0\u00b0C<\/td>\n<td style=\"width: 227px;\">\n<ul>\n<li>in water: 26\u00a0g\u00b7l<sup>\u22121<\/sup>\u00a0(18\u00a0\u00b0C)<sup id=\"cite_ref-Merck_1-2\"><\/sup><\/li>\n<li>not in methanol, benzole and chloroform<sup id=\"cite_ref-3\"><a href=\"http:\/\/de.wikipedia.org\/wiki\/Glutamin#cite_note-3\"><br \/>\n<\/a><\/sup><\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<hr \/>\n<p><sup>1<\/sup> Depending on the type of atom it was <sup>1<\/sup>H, <sup>13<\/sup>C or <sup>15<\/sup>N chemical shift. <sup>1<\/sup>H und <sup>13<\/sup>C relative to TMS and <sup>15<\/sup>N relative to liquid ammonia<\/p>\n<p><sup>2<\/sup> Number of individual chemical shift data for averaging according to [2]<\/p>\n<p><sup>3<\/sup> with Alanine as neighborhood in the hexapeptide Gly-Gly-X-Ala-Gly-Gly [3]<\/p>\n<p><sup>4<\/sup> with Proline as neighborhood in the hexapeptide Gly-Gly-X-Pro-Gly-Gly [3]<\/p>\n<hr>\n<h3>3D- Modell<\/h3>\n<div style=\"height: 400px; width: 400px; border-style: solid; position: relative;\" class='viewer_3Dmoljs' data-href='https:\/\/wissen.science-and-fun.de\/molekel\/glutamin.sdf' data-backgroundcolor='0xffffff' data-style='stick' data-typ='sdf'><\/div>\n<p><\/p>\n<p>sources:<\/p>\n<p>[1] &#8220;BioMagResBank&#8221;, Eldon L. Ulrich; Hideo Akutsu; Jurgen F. Doreleijers; Yoko Harano; Yannis E. Ioannidis; Jundong Lin; Miron Livny; Steve Mading; Dimitri Maziuk; Zachary Miller; Eiichi Nakatani; Christopher F. Schulte; David E. Tolmie; R. Kent Wenger; Hongyang Yao; John L. Markley; Nucleic Acids Research 36, D402-D408 (2008) doi: 10.1093\/nar\/gkm957<\/p>\n<p>[2] http:\/\/www.bmrb.wisc.edu\/ last visit march 2017<\/p>\n<p>[3] David S. Wishart, Colin G. Bigam, Arne Holm, Robert S. Hodges, Brian D. Sykes; Journal of Biomolecular NMR<br \/>\nJanuary 1995, Volume 5, Issue 1, pp 67-81 doi:10.1007\/BF00227471<\/p>\n<p>[4] Wikipedia\u00a0http:\/\/de.wikipedia.org\/wiki\/Aminos%C3%A4uren (last visit january 2014)<\/p>\n<p>[5] Wikipedia http:\/\/de.wikipedia.org\/wiki\/Asparagin\u00a0(last visit january 2014)<\/p>\n<p>3D Mol: Nicholas Rego and David Koes<br \/>\n3Dmol.js: molecular visualization with WebGL<br \/>\nBioinformatics (2015) 31 (8): 1322-1324 doi:10.1093\/bioinformatics\/btu829<\/p>\n","protected":false},"excerpt":{"rendered":"<p>NMR-Data [1] of Glutamine: Atom Atomtyp chemical shift [ppm]1 Random Coil chem. shift\u00a03 Random Coil chem. shift\u00a04 average standard deviation entries2 H H \u00a08.218 \u00a00.684 \u00a033299 \u00a08.32 \u00a08.29 H\u03b1 H \u00a04.268 \u00a00.439 \u00a025740 \u00a04.34 \u00a04.65 H\u03b22 H \u00a02.042 \u00a00.273 \u00a023494 \u00a02.12 \u00a02.09 H\u03b23 H \u00a02.012 \u00a00.317 \u00a022302 \u00a01.99 \u00a01.93 H\u03b32 H \u00a02.312 \u00a00.351 \u00a022128 \u00a02.36 &hellip; <\/p>\n<p><a class=\"more-link btn\" href=\"https:\/\/wissen.science-and-fun.de\/chemistry\/2017\/04\/09\/glutamine-gln-q\/\">Continue reading<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"wprm-recipe-roundup-name":"","wprm-recipe-roundup-description":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[5,4],"tags":[98,106,99],"class_list":["post-1544","post","type-post","status-publish","format-standard","hentry","category-nmr","category-spectroscopy","tag-bio-nmr","tag-glutamine","tag-nmr","item-wrap"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - 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